Baccano!

In 1711, alchemists who had left their homeland received a gift from the Devil aboard the Atlantic: the Elixir of Immortality. To monopolize the recipe for this elixir, those on the secret ship began killing one another. In the New York underworld of the 1930s, the talented young mafioso Firo, a pair of bumbling thieves, an immortal alchemist and his assistant who have lived for 200 years, along with Firo's childhood friend, a wealthy heiress, a member of a terrorist organization, a young train conductor... These people, originally unrelated to each other, find their fates becoming intricately intertwined due to the resurgence of the Elixir of Immortality. Departing from Chicago with New York as their destination, the Wheel of Fate brings everyone together on a train crossing the American continent. However, not all passengers on this train are "human." The legendary ghost reappears, and passengers begin disappearing one by one, starting from the last car.